File:Groupphoto 20161208 crop.jpg

2016-12-11T15:57:08Z

Kskim:

Welcome to Network Biology Laboratory

2016-04-13T14:33:38Z

Kskim:

__NOTOC__

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[[File :P4070576 2.jpg|580px|center|middle|Main Photo]]

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=== Research Keyword Cloud ===
<div>{{#widget:AddHtml|content=<img src="../wiki/cloud.jpg" alt="Word Cloud from Abstraction below publications" title="Word Cloud of NBL Publications' Abstract" />}}</div>
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=== Oral Presentation ===
{|class=wikitable style="text-align:center;"
|-
|style="width:65px"| JE Shim*
|style="width:65px"| T Lee
|style="width:65px"| HJ Han
|-
| KS Kim
| ER Kim
| CY Kim
|-
| DS Bae
| SM Yang
| MY Lee
|}
|

=== Visitors Trend ===
[http://www2.clustrmaps.com/user/563d3fa7 http://www2.clustrmaps.com/stats/maps-no_clusters/www.netbiolab.org-thumb.jpg]
|-
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===Contact Informations===
<pre>
Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
Office: Engineering Research Park B118DA
+82-70-8625-5205
</pre>
|}

Media & Outreach

2015-08-01T03:05:00Z

Kskim:

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*2015 April 16
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연세소식
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[[media:Yonseisosik.pdf|이인석 교수 연구팀, 빅데이터 기반 유전자네트워크를 이용한 작물연구 관련 종설과 연구논문 발표]]
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*2014 July 16
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ScienceTimes
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[http://www.sciencetimes.co.kr/?news=%EC%A7%88%EB%B3%91-%EC%B9%98%EB%A3%8C-%EC%A0%95%ED%99%95%ED%95%9C-%EC%9B%90%EC%9D%B8%EC%A7%84%EB%8B%A8%EC%9D%B4-%EB%A8%BC%EC%A0%80%EC%A3%A0 “질병 치료, 정확한 원인진단이 먼저죠”]
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*2014 June 25
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한국경제
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[[media:morphin_article.jpg|유전자-질환 연관성 예측시스템 나왔다]]
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*2014 June 24
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YTN Science
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[https://www.youtube.com/watch?v=tpiGS5cArY4 유전자 상관관계 네트워크로 질환 연구]
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*2012 Nov 22
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5th RECOMB Conference on Regulatory and Systems Genomics
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[http://recomb-2012.c2b2.columbia.edu/?q=node/29 HumanNet 논문(Genome Research 21:1109)이 2011년 시스템생물학 분야에서 가장 영향력 있는 논문 탑10에 선정]
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*2011 Nov 9
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YTN Science 24
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[http://www.sciencetv.kr/program/program_view.php?s_mcd=0184&s_hcd=01&key=201111091542149116 벼 유전자 네트워크 완성...슈퍼 벼 생산]
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*2011 Nov 1
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KBS News
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[http://news.kbs.co.kr/science/2011/11/01/2381579.html 병충해·홍수에 강한 ‘슈퍼 벼’ 개발]

보도내용 중 이화여대연구진을 연세대학교 연구진 으로 정정합니다
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*2011 Nov 1
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Dong-A Ilbo Channel A News
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[http://news.donga.com/3/all/20111104/41645483/1 벼 유전자 네트워크]
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*2011 Oct 3
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The financial news
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[[media:Media_n_Outreach_019.pdf|한국 과학의 미래，이젠 노벨상이다(2): ④ 미로처럼 얽힌 유전자 네트워크 지도화]]

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*2011 Aug 31
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MBN News
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[http://tvnews.media.daum.net/view.html?cateid=100000&newsid=20110831141310630&p=mbn[수요일에 만난 과학자] 유전자의 소셜 네트워크를 밝힌다
]

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*2011 May
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KBS News
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[http://news.kbs.co.kr/science/2011/05/12/2290284.html '휴먼 넷' 난치성 질환 치료 해법 찾아]

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*2011 May
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News Letter Yonsei
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[[media:Media_n_Outreach_018.pdf|유전자 소셜 네트워크로 암, 당뇨 조절 유전자 발굴법 개발]]

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*2011 May
|width="200" align="center"|
Digital times
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[[media:Media_n_Outreach_017.pdf|유전자 네트워크로 질병 규명]]
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The Kyunghyang Daily News
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[[media:Media_n_Outreach_017.pdf|유전자와 유전자의 '관계' 네트워크 지도 개발]]
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*2011 Feb
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The Chosunilbo
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[[media:Media_n_Outreach_016.pdf|인간 세상 네트워크 닮은 식물 유전자의 세계]]

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*2011 Feb
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Science : Visualization Challenge
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[[media:Media_n_Outreach_015.pdf|AraNet: A Genome-wide Gene Function Association Network for ''Arabidopsis thaliana'']]

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*2010 Nov
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POSCO News
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[[media:Media_n_Outreach_014.pdf|'2011청암펠로우(이인석 교수 선정)]]

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*2010 Sep
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News Letter Yonsei
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[[media:Media_n_Outreach_013.pdf|생명공학과 학부생 연구결과 국제 권위 저널에 실려 (김이루 학생)]]

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*2010 Aug
|width="200" align="center"|
The Chosunilbo
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[[media:Media_n_Outreach_012.pdf|연세대 학부생 생명공학 논문 국제학술지 게재 (김이루 학생)]]

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*2010 Aug
|width="200" align="center"|
The Science & technology
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[[media:Media_n_Outreach_011.pdf|유전자네트워크 이용한 복잡질환 조절유전자 예측방법 개발 (논단)]]

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*2010 Jul
|width="200" align="center"|
News Letter Yonsei
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[[media:Media_n_Outreach_010.pdf|이인석 교수, 암,당뇨 등의 새로운 치료법 가능성 열어]]

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*2010 Jun
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Kukminilbo
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[[media:Media_n_Outreach_009.pdf|암,당뇨병 등 복잡 질환 조절 유전자 효율적으로 찾아내는 새로운 방법 개발]]
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|width="200" align="center"|
Seoul newspaper
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[[media:Media_n_Outreach_009.pdf|암,당뇨 등 '조절 유전자 예측법' 개발]]
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*2010 Mar
|width="200" align="center"|
The Yonsei Chunchu (Daily newspaper of Yonsei University)
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[[media:Media_n_Outreach_008.pdf|'예측'이 가장 쉬웠어요]]

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{|border="0"
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*2010 Mar
|width="200" align="center"|
News Letter Yonsei
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[[media:Media_n_Outreach_007.pdf|이인석교수, 세계 최대 식물유전자네트워크 규명]]

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{|border="0"
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*2010 Mar
|width="200" align="center"|
The Science & technology
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[[media:Media_n_Outreach_006.pdf|네트워크 이용한 새롭고 효율적인 유전학 연구 기법 제시 (논단)]]

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*2010 Mar
|width="200" align="center"|
Biomedical Computation Review (IT magazine)
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[[media:Media_n_Outreach_005.pdf|A Tipping Point for Function Prediction]]

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{|border="0"
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*2010 Feb
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The Korea Economic Daily
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[[media:Media_n_Outreach_004.pdf|식물도 사람처럼 유전자 네트워크가 있었네!]]

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{|border="0" width="730"
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*2010 Feb
|width="200" align="center"|
The Chosunilbo
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[[media:Media_n_Outreach_003.pdf|유전자 숨겨진 기능 쉽게 찾는 '네트워크 기술']]

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*2010 Feb
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Science Daily
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[[media:Media_n_Outreach_002.pdf|Gene Function Discovery: New Computation Model Predicts Gene Function]]

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*2008 Dec
|width="200" align="center"|
KSMCB (Korean Society for Molecular and Cellular Biology) news
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[[media:Media_n_Outreach_001.pdf|기능성유전자 네트워크를 이용한 생물학 연구 (논단)]]

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Welcome to Network Biology Laboratory

2015-07-28T06:16:23Z

Kskim: /* Oral Presentation */

__NOTOC__

{|border = "0" valign="top"
|rowspan="2" style="padding-right:20px;"|
[[File :Groupphoto_20150601_5.jpeg|580px|center|middle|Main Photo]]

|colspan=2|
=== Research Keyword Cloud ===
<div>{{#widget:AddHtml|content=<img src="cloud.jpg" alt="Word Cloud from Abstraction below publications" title="Word Cloud of NBL Publications' Abstract" />}}</div>
|-
|
=== Oral Presentation ===
<pre>
JE Shim | T Lee
HJ Han | HS Shim
KS Kim | ER Kim
CY Kim** | DS Bae | BH Kang
</pre>
|

=== Visitors Trend ===
[http://www2.clustrmaps.com/user/563d3fa7 http://www2.clustrmaps.com/stats/maps-no_clusters/www.netbiolab.org-thumb.jpg]
|-
|colspan=3|
===Contact Informations===
<pre>
Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
Office: Engineering Research Park B118DA
+82-70-8625-5205
</pre>
|}

Publications

2015-06-21T08:27:50Z

Kskim:

* [http://scholar.google.com/citations?user=3uHQIOkAAAAJ Google Scholar citation report]
* [http://www.researcherid.com/rid/F-7722-2010 {{#widget:AddHtml|content=<img src='http://labs.researcherid.com/mashlets/badge/rid-idsymbol4.gif' border='0' />}}]

* '*' co-corresponding authorship
==2015==
*48. Shim JE, Hwang S, '''Lee I''', Pathway-Dependent Effectiveness of Network Algorithms for Gene Prioritization, '''''PLoS One''''' 2015 Jun 19 [http://www.ncbi.nlm.nih.gov/pubmed/26091506 pubmed]
*47. Han H, Shim H, Shin D, Shim JE, Ko Y, Shin J, Kim H, Cho A, Kim E, Lee T, Kim H, Kim K, Yang S, Bae D, Yun A, Kim S, Kim CY, Cho HJ, Kang B, Shin S, '''Lee I''', TRRUST: a reference database of human transcriptional regulatory interactions, '''''Scientific Reports''''' 2015 Jun 12 [http://www.ncbi.nlm.nih.gov/pubmed/26066708 pubmed]
*46. Shin J, Yang S, Kim E, Kim CY, Shim H, Cho A, Kim H, Hwang S, Shim JE, '''Lee I''', FlyNet: a versatile network prioritization server for the Drosophila community, '''''Nucleic Acids Research''''' 2015 May 5 [http://www.ncbi.nlm.nih.gov/pubmed/25943544 pubmed]
*45. '''Lee I''', Mockler TC, Editorial overview: Genome studies and molecular genetics: data-driven approaches to genotype-to-phenotype studies in crops, '''''Current Opinion in Plant Biology''''' 2015 Mar 26 [http://www.ncbi.nlm.nih.gov/pubmed/25817324 pubmed]
*44. Lee T, Oh T, Yang S, Shin J, Hwang S, Kim CY, Kim H, Shim H, Shim JE, Ronald PC, '''Lee I''', RiceNet v2: an improved network prioritization server for rice genes, '''''Nucleic Acids Research''''' 2015 Mar 26 [http://www.ncbi.nlm.nih.gov/pubmed/25813048 pubmed]
*43. '''Lee I''', Kim E, Marcotte EM, Modes of Interaction between Individuals Dominate the Topologies of Real World Networks, '''''Plos One''''' 2015 Mar 20 [http://www.ncbi.nlm.nih.gov/pubmed/25793969 Pubmed]
*42. Kim H, Jung KW, Maeng S, Chen YL, Shin J, Shim JE, Hwang S, Janbon G, Kim T, Heitman J, Bahn YS, '''Lee I''', Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans, '''''Scientific Reports''''' 2015 Mar 5 [http://www.ncbi.nlm.nih.gov/pubmed/25739925 Pubmed]
*41. Lee T, Kim H, '''Lee I''', Network-assisted crop systems genetics: network inference and integrative analysis, '''''Current Opinion in Plant Biology''''' 2015 Feb 16 [http://www.ncbi.nlm.nih.gov/pubmed/25698380 Pubmed]
*40. Kim T, Dreher K, Nilo-Poyanco R, '''Lee I''', Fiehn O, Lange BM, Nikolau BJ, Sumner L, Welti R, Wurtele ES, Rhee SY, Patterns of metabolite changes identified from large-scale gene perturbations in Arabidopsis thaliana using a genome-scale metabolic network, '''''Plant Physiology''''' 2015 Feb 10 [http://www.ncbi.nlm.nih.gov/pubmed/25670818 Pubmed]
*39. Kim H, Shim JE, Shin J, '''Lee I''', EcoliNet: a database of cofunctional gene network for Escherichia coli, '''''Database''''' 2015 Feb 2 [http://www.ncbi.nlm.nih.gov/pubmed/25650278 Pubmed]
*38. Lee T, Yang S, Kim E, Ko Y, Hwang S, Shin J, Shim JE, Shim H, Kim H, Kim C, '''Lee I''', AraNet v2: an improved database of co-functional gene networks for the study of Arabidopsis thaliana and 27 other nonmodel plant species, '''''Nucleic Acids Research''''' 2015 Jan [http://www.ncbi.nlm.nih.gov/pubmed/25355510 Pubmed]

==2014==
*37. Hwang S, Kim E, Yang S, Marcotte EM, '''Lee I''', MORPHIN: a web tool for human disease research by projecting model organism biology onto a human integrated gene network, '''''Nucleic Acids Res''''' 2014 Jul;42(Web server issue):W147-53. [http://www.ncbi.nlm.nih.gov/pubmed/24861622 Pubmed]
*36. '''Lee I''', A showcase of future plant biology: moving towards next-generation plant genetics assisted by genome sequencing and systems biology, '''''Genome Biology''''', 2014 May 23;15(5):305. [http://www.ncbi.nlm.nih.gov/pubmed/25001400 Pubmed]
*35. Ara Cho, Junha Shin, Sohyun Hwang, Chanyoung Kim, Hongsuk Shim, Hyojin Kim, Hanhae Kim, '''Insuk Lee''', WormNet v3: a network-assisted hypothesis-generating server for Caenorhabditis elegans, '''''Nucleic Acids Res'''''. 2014 May 9 [http://www.ncbi.nlm.nih.gov/pubmed/24813450 Pubmed]
*34. Junha Shin, Tak Lee, Hanhae Kim and '''Insuk Lee''', Complementarity between distance- and probability-based methods of gene neighbourhood identification for pathway reconstruction. '''''Mol. BioSyst.''''', 10 (1), 24 - 29., (2014) [http://www.ncbi.nlm.nih.gov/pubmed/24194096 Pubmed]
*33. Hanhae Kim, Junha Shin, Eiru Kim, Hyojin Kim, Sohyun Hwang, Jung Eun Shim, '''Insuk Lee''', YeastNet v3: a public database of data-specific and integrated functional gene networks for Saccharomyces cerevisiae. '''''Nucleic Acids Research''''' 42 (D1): D731-D736., (2014) [http://www.ncbi.nlm.nih.gov/pubmed/24165882 Pubmed]

==2013==
*32. Eiru Kim, Hanhae Kim and '''Insuk Lee''', JiffyNet: a web-based instant protein network modeler for newly sequenced species. '''''Nucleic Acids Research''''' 41 (W1): W192-W197., (2013) [http://www.ncbi.nlm.nih.gov/pubmed/23685435 Pubmed][http://nar.oxfordjournals.org/content/early/2013/05/17/nar.gkt419.full.pdf+html pdf]
*31. '''Insuk Lee''', Network approaches to the genetic dissection of phenotypes in animals and humans. '''''Animal Cells and Systems''''' Vol.17,No.2,75-79(2013)[http://www.tandfonline.com/doi/abs/10.1080/19768354.2013.789076 Link]

==2012==
*30. Peggy I Wang, Sohyun Hwang, Rodney P Kincaid, Christopher S Sullivan, '''Insuk Lee*''', and Edward M Marcotte*. RIDDLE: Reflective diffusion and local extension reveal functional associations for unannotated gene sets via proximity in a gene network. '''''Genome Biology''''' 13:R125 (2012)[http://www.ncbi.nlm.nih.gov/pubmed/23268829 pubmed]
*29. Lee Chae*, '''Insuk Lee*''', Junha Shin, and Seung Yon Rhee*. Towards understanding how molecular networks evolve in plant. '''''Current Opinion in Plant Biology''''' 15:177-184 (2012)[http://www.ncbi.nlm.nih.gov/pubmed/22280840 pubmed] [[media:CurrOpinPlantBiol 15-177.pdf|pdf]]
*28. Stephanie M. Quanbeck, Libuse Brachova, Alexis A. Campbell, Xin Guan, Ann Perera, Kun He, Seung Y. Rhee, Preeti Bais, Julie A. Dickerson, Philip Dixon, Gert Wohlgemuth, Oliver Fiehn, Lenore Barken, Iris Lange, B. Markus Lange, '''Insuk Lee''', Diego Cortes, Carolina Salazar, Joel Shuman, Vladimir Shulaev, David V. Huhman, Lloyd W. Sumner, Mary R. Roth, Ruth Welti, Hilal Ilarslan, Eve S. Wurtele, and Basil J. Nikolau. Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of “unknown function”. '''''Frontiers in Plant Science''''' 3:1-12 (2012) [http://www.ncbi.nlm.nih.gov/pubmed/22645570/ pubmed][[media:Fpls-03-00015.pdf|pdf]]

==2011==
*27. '''Insuk Lee*''', Young-Su Seo, Dusica Coltrane, Sohyun Hwang, Taeyun Oh, Edward M. Marcotte*, and Pamela C. Ronald*. Genetic dissection of the biotic stress response using a genome-scale gene network for rice. '''''PNAS''''' 108(45):18548-53 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/22042862 pubmed] [[media:PNAS-2011-Lee-18548-53.pdf|pdf]]

*26. Sohyun Hwang, Seung Y. Rhee*, Edward M. Marcotte*, and '''Insuk Lee*'''. Systematic prediction of candidate gene function associated to phenotype traits using the probabilistic functional gene network of Arabidopsis thaliana. '''''Nature Protocols''''' 6:1429-1442 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21886106 pubmed][[media:2011.08.25.online.nprot.2011.372.pdf|pdf]]

*25. '''Insuk Lee''', Probabilistic functional gene societies. '''''Progress in Biophysics and Molecular Biology''''' 106:435-442 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21281658 pubmed] [[media:Publications_023_n.pdf|pdf]]

*24. '''Insuk Lee*''', U. Martin Blom, Peggy I. Wang, Jung Eun Shim, and Edward M. Marcotte*. Prioritizing candidate disease genes by network-based boosting of genome-wide association data. '''''Genome Research''''' 21:1109-1121 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21536720 pubmed] [[media:Publications_025_n.pdf|pdf]]

*23. Young-Su Seo, Mawsheng Chern, Laura E. Bartley, Muho Han, Ki-Hong Jung, '''Insuk Lee''', Harkamal Walia, Todd Richter, Xia Xu, Peijian Cao, Wei Bai, Rajeshwari Ramanan, Fawn Amonpant, Loganathan Arul, Patrick E. Canlas, Randy Ruan, Chang-Jin Park, Xuewel Chen, Sohyun Hwang, Jong-Seong Jeon, and Pamela C. Ronald. Towards establishment of a rice stress response interactome. '''''PLoS Genetics''''' 7(4):e1002020 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21533176 pubmed] [[media:Publications_024.pdf|pdf]]

==2010==
*22. Ni Huang, '''Insuk Lee''', Edward M.Marcotte, Matthew E.Hurles, Characterising and predicting haploinsufficiency in the human genome, '''''PLoS Genet.''''' 6(10):e1001154(2010) [http://www.ncbi.nlm.nih.gov/pubmed/20976243 pubmed] [[media:Publications_022.pdf|pdf]]

*21. Eiru Kim, Jaeyoon Shin and '''Insuk Lee''', Assessment of effectiveness of the network-guided genetic screen, '''''Mol Biosyst.''''' 6:1803-1806(2010) [http://www.ncbi.nlm.nih.gov/pubmed/20697632 pubmed] [[media:Publications_021.pdf|pdf]]

*20. '''Insuk Lee*''', Ben Lehner, Tanya Vavouri, Junha Shin, Andrew G. Fraser, and Edward M. Marcotte, Predicting genetic modifier loci using functional gene networks, '''''Genome Research''''', 20:1143-1153(2010) . co-corresponding author [http://www.ncbi.nlm.nih.gov/pubmed/20538624 pubmed] [[media:Publications_020.pdf|pdf]]

*19. '''Insuk Lee*''', Bindu Ambaru, Pranjali Thakkar, Edward M Marcotte*, Seung Y Rhee*, Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana, '''''Nature Biotechnology''''', 28:149-156 (2010). ''co-corresponding author'' [http://www.ncbi.nlm.nih.gov/pubmed/20118918 pubmed] [[media:Publications_019.pdf|pdf]]
==2009==
*18. '''Insuk Lee''' and Edward Marcotte. Effects of functional bias on supervised learning of a gene network model. '''In Methods in Molecular Biology''' Vol. 541, Computational Systems Biology (ed. R. Ireton, K. Montgomery, J. McDermott, R. Samudrala, R. Bumgarner). Totowa, THE HUMANA. p463-475 (2009) [http://www.ncbi.nlm.nih.gov/pubmed/19381535 pubmed] [[media:Publications_018.pdf|pdf]]

*17. Zhihua Li, '''Insuk Lee''', Emily Moradi, Nai-Jung Hung, Arlen W. Johnson, Edward M. Marcotte, Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics, '''''PLoS Biology''''', 7(10):e1000213 (2009) [http://www.ncbi.nlm.nih.gov/pubmed/19806183 pubmed] [[media:Publications_017.pdf|pdf]]

*16. Ryan S. Gray, Philip B. Abitua, Bogdan J. Wlodarczyk, Heather L. Szabo-Rogers, Otis Blanchard, '''Insuk Lee''', Greg S. Weiss, Karen J. Liu, Edward M. Marcotte, John B. Wallingford, Richard H. Finnell. The planar cell polarity effector protein Fuz is essential for targeted membrane trafficking, ciliogenesis, and mouse embryonic development, '''''Nature Cell Biology''''' 11:1225-32 (2009) '''''*Cover story''''' [http://www.ncbi.nlm.nih.gov/pubmed/19767740 pubmed] [[media:Publications_016.pdf|pdf]]
==2008==
*15. Ben Lehner* and '''Insuk Lee*'''. Network-guided genetic screening: building, testing, and using gene networks to predict gene function. '''''Brief. Funct. Genomic'''''. 7:217-227 (2008). '''''co-corresponding author''''' [http://www.ncbi.nlm.nih.gov/pubmed/18445637 pubmed] [[media:Publications_015.pdf|pdf]]

*14. '''Insuk Lee''' and Edward Marcotte. Integrating Functional Genomics Data. '''In Methods in Molecular Biology''' Vol. 453, Bioinformatics Vol. II (ed. Jonathan Keith). Totowa, THE HUMANA. p267-278 (2008) [http://www.ncbi.nlm.nih.gov/pubmed/18712309 pubmed] [[media:Publications_014.pdf|pdf]]

*13. '''Insuk Lee''', Ben Lehner, Catriona Crombie, Wendy Wong, Andrew G. Fraser, Edward M. Marcotte. A single gene network accurately predicts phenotypic effects of gene perturbation in ''Caenorhabditis elegans''. '''''Nature Genetics''''' 40:181-188 (2008). '''''*Cover story''''' [http://www.ncbi.nlm.nih.gov/pubmed/18223650 pubmed] [[media:Publications_013.pdf|pdf]]<br />This paper was the subject of the following commentary (Natalie de Souza, Networking on organism. Nature Methods 5:217), and minireviews (Von Stetina S. E. and Mango S. E. Wormnet: a crystal ball for Caenorhabditis elegans. Genome Biology 9:226. Borgwardt K. Predicting phenotypic effects of gene perturbations in C. elegans using an integrated network model. BioEssays 30:707)

==Before 2007==
*12. '''Insuk Lee''', Rammohan Narayanaswamy, Edward Marcotte. Bioinformatic prediction of yeast gene function. '''In METHOD IN MICROBIOLOGY''' Vol. 36, Yeast Gene Analysis (ed. Ian Stansfield and Mike Stark), Elsevier. p597-628, (2007) [[media:Publications_012.pdf|pdf]]

*11. Kris McGary, '''Insuk Lee''', Edward M. Marcotte. Broad network-based predictability of S. cerevisiae gene loss-of-function phenotypes. '''''Genome Biology''''' 8:R258 (2007) [http://www.ncbi.nlm.nih.gov/pubmed/18053250 pubmed] [[media:Publications_011.pdf|pdf]]

*10. '''Insuk Lee''', Zhihua Li, and Edward M. Marcotte. An improved bias-reduced probabilistic functional gene network of baker’s yeast ''Saccharomyces cerevisiae''. '''''PLOS One''''' 2:e988 (2007) [http://www.ncbi.nlm.nih.gov/pubmed/17912365 pubmed] [[media:Publications_010.pdf|pdf]]

*9. Hart G. Traver, '''Insuk Lee''', Edward Marcotte. A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. '''''BMC Bioinformatic''''' 8:236 (2007) [http://www.ncbi.nlm.nih.gov/pubmed/17605818 pubmed] [[media:Publications_009.pdf|pdf]]

*8. Insuk Lee, Shailesh V. Date, Alex T. Adai, Edward Marcotte. A Probabilistic functional network of yeast genes. '''''Science''''' 306:1555-1558, (2004) [http://www.ncbi.nlm.nih.gov/pubmed/15567862 pubmed] [[media:Publications_008.pdf|pdf]]

*7. Bork, P., Jensen, L.J., Von Mering, C., Ramani, A.K., '''Lee I''', Marcotte, E.M. Protein interaction networks from yeast to human. '''''Curr. Opin. Struct. Biol.''''' 14:292-9, (2004) [http://www.ncbi.nlm.nih.gov/pubmed/15193308 pubmed] [[media:Publications_007.pdf|pdf]]

*6. '''Insuk Lee''' and Rasika Harshey. Patterns of Sequence conservation at termini of LTR retrotransposons and DNA transposons in the human genome: Lessons from phage Mu. '''''Nucleic Acids Res.''''' 31:4531-4540, (2003)

*5. '''Insuk Lee''' and Rasika Harshey. The conserved CA/TG motif at Mu termini: T specifies stable transpososome assembly. '''''J. Mol. Biol.''''' 330:261-275, (2003)

*4. '''Insuk Lee''' and Rasika Harshey. Importance of the conserved CA dinucleotide at Mu termini. '''''J. Mol. Biol.''''' 314:433-444, (2001)

*3. Xue, Y., Bai, X., '''Lee, I.''', Kallstrom, G., Ho, J., Brown, J., Stevens, A., and Johnson, A. W. Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p. '''''Mol. Cell. Biol.''''' 20:4006-4015, (2000)

*2. Liu, J., Gong, Y., Prakash, O., Wen, L., '''Lee, I'''., Huang J.,-K., and Krishnamoorthi, R. NMR studies of internal dynamics of serine proteinase protein inhibitors: Binding region mobilities of intact and reactive-site hydrolyzed CMTI-III of the squash family and comparison with those of counterparts of CMTI-V of the potato I family. '''''Protein Science''''' 7:132-141, (1998)

*1. Wen, L., '''Lee, I.''', Chen, G., Huang, J.,-K., Gong, Y., and Krishnamoorthi, R. Changing the inhibitory specificity and function of CMTI-V by site-directed mutagenesis. '''''Biochem. Biophys. Res. Commun.''''' 207:897-902, (1995)

Services

2015-06-16T02:11:43Z

Kskim:

__NOTOC__
=='''Genome-scale functional gene networks'''==
==''Animal''==
{|border="0" width="600"
|align="center"|[[file:WormNetv3.jpg|150px|link=http://www.inetbio.org/wormnet]]
|align="center"|[[file:Flynet.png|150px|link=http://www.inetbio.org/flynet]]
|align="center"|[[file:Tools_HumanNetLogo.jpg|150px|link=http://www.functionalnet.org/humannet]]
|-
|align="center"|''Caenorhabditis elegans''
|align="center"|''Drosophila melanogaster''
|align="center"|''Homo sapiens''
|}
==''Plant''==
{|border="0" width="400"
|align="center"|[[File:Aranet_v2.jpg|150px|link=http://www.inetbio.org/aranet]]
|align="center"|[[file:RiceNetv2 logo.png|150px|link=http://www.inetbio.org/ricenet]]
|-
|align="center"|''Arabidopsis thaliana''
|align="center"|''Oryza sativa''
|}
==''Microbe''==
{|border="0" width="600"
|align="center"|[[File:EcoliNet.png|150px|link=http://www.inetbio.org/ecolinet]]
|align="center"|[[File:Tools_YesatNetLogo.jpg|150px|link=http://www.inetbio.org/yeastnet]]
|align="center"|[[file:CryptoNet.png|150px|link=http://www.inetbio.org/cryptonet]]
|-
|align="center"|''Escherichia coli''
|align="center"|''Saccharomyces cerevisiae''
|align="center"|''Cryptococcus neoformans''
|}

=='''RIDDLE: For network-assisted Gene Set Analysis'''==
[[File:Cover title riddle.jpg|150px|link=http://www.functionalnet.org/riddle]] RIDDLE (Reflective diffusion and local extension) is currently available for only human genes.
=='''MORPHIN: For the study of human diseases based on model organism pathways'''==
[[File:Logo morphin.png|150px|link=http://www.inetbio.org/morphin/]] Morphin (Model Organisms Projected on a Human Integrated Gene Network) is currently available.
=='''JiffyNet: A gene network inference server for newly sequenced species'''==
[[File:Jiffynetlogo4 small.jpg |150px|link=http://www.jiffynet.org]] Jiffy (instant) gene network modeler for newly sequenced species
=='''TRRUST: a reference database of human transcriptional regulatory interactions'''==
[[File:TRRUST_logo.jpg |150px|link=http://http://www.grnpedia.org/trrust/]] TRRUST (Transcriptional Regulatory relationships Unraveled by Sentence-based Text mining) is currently available for only human genes.

File:TRRUST logo.jpg

2015-06-16T02:09:43Z

Kskim:

Publications

2015-06-16T02:07:26Z

Kskim: /* 2015 */

* [http://scholar.google.com/citations?user=3uHQIOkAAAAJ Google Scholar citation report]
* [http://www.researcherid.com/rid/F-7722-2010 {{#widget:AddHtml|content=<img src='http://labs.researcherid.com/mashlets/badge/rid-idsymbol4.gif' border='0' />}}]

* '*' co-corresponding authorship
==2015==
*47. Han H, Shim H, Shin D, Shim JE, Ko Y, Shin J, Kim H, Cho A, Kim E, Lee T, Kim H, Kim K, Yang S, Bae D, Yun A, Kim S, Kim CY, Cho HJ, Kang B, Shin S, '''Lee I''', TRRUST: a reference database of human transcriptional regulatory interactions, '''''Scientific Reports''''' 2015 Jun 12 [http://www.ncbi.nlm.nih.gov/pubmed/26066708 pubmed]
*46. Shin J, Yang S, Kim E, Kim CY, Shim H, Cho A, Kim H, Hwang S, Shim JE, '''Lee I''', FlyNet: a versatile network prioritization server for the Drosophila community, '''''Nucleic Acids Research''''' 2015 May 5 [http://www.ncbi.nlm.nih.gov/pubmed/25943544 pubmed]
*45. '''Lee I''', Mockler TC, Editorial overview: Genome studies and molecular genetics: data-driven approaches to genotype-to-phenotype studies in crops, '''''Current Opinion in Plant Biology''''' 2015 Mar 26 [http://www.ncbi.nlm.nih.gov/pubmed/25817324 pubmed]
*44. Lee T, Oh T, Yang S, Shin J, Hwang S, Kim CY, Kim H, Shim H, Shim JE, Ronald PC, '''Lee I''', RiceNet v2: an improved network prioritization server for rice genes, '''''Nucleic Acids Research''''' 2015 Mar 26 [http://www.ncbi.nlm.nih.gov/pubmed/25813048 pubmed]
*43. '''Lee I''', Kim E, Marcotte EM, Modes of Interaction between Individuals Dominate the Topologies of Real World Networks, '''''Plos One''''' 2015 Mar 20 [http://www.ncbi.nlm.nih.gov/pubmed/25793969 Pubmed]
*42. Kim H, Jung KW, Maeng S, Chen YL, Shin J, Shim JE, Hwang S, Janbon G, Kim T, Heitman J, Bahn YS, '''Lee I''', Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans, '''''Scientific Reports''''' 2015 Mar 5 [http://www.ncbi.nlm.nih.gov/pubmed/25739925 Pubmed]
*41. Lee T, Kim H, '''Lee I''', Network-assisted crop systems genetics: network inference and integrative analysis, '''''Current Opinion in Plant Biology''''' 2015 Feb 16 [http://www.ncbi.nlm.nih.gov/pubmed/25698380 Pubmed]
*40. Kim T, Dreher K, Nilo-Poyanco R, '''Lee I''', Fiehn O, Lange BM, Nikolau BJ, Sumner L, Welti R, Wurtele ES, Rhee SY, Patterns of metabolite changes identified from large-scale gene perturbations in Arabidopsis thaliana using a genome-scale metabolic network, '''''Plant Physiology''''' 2015 Feb 10 [http://www.ncbi.nlm.nih.gov/pubmed/25670818 Pubmed]
*39. Kim H, Shim JE, Shin J, '''Lee I''', EcoliNet: a database of cofunctional gene network for Escherichia coli, '''''Database''''' 2015 Feb 2 [http://www.ncbi.nlm.nih.gov/pubmed/25650278 Pubmed]
*38. Lee T, Yang S, Kim E, Ko Y, Hwang S, Shin J, Shim JE, Shim H, Kim H, Kim C, '''Lee I''', AraNet v2: an improved database of co-functional gene networks for the study of Arabidopsis thaliana and 27 other nonmodel plant species, '''''Nucleic Acids Research''''' 2015 Jan [http://www.ncbi.nlm.nih.gov/pubmed/25355510 Pubmed]

==2014==
*37. Hwang S, Kim E, Yang S, Marcotte EM, '''Lee I''', MORPHIN: a web tool for human disease research by projecting model organism biology onto a human integrated gene network, '''''Nucleic Acids Res''''' 2014 Jul;42(Web server issue):W147-53. [http://www.ncbi.nlm.nih.gov/pubmed/24861622 Pubmed]
*36. '''Lee I''', A showcase of future plant biology: moving towards next-generation plant genetics assisted by genome sequencing and systems biology, '''''Genome Biology''''', 2014 May 23;15(5):305. [http://www.ncbi.nlm.nih.gov/pubmed/25001400 Pubmed]
*35. Ara Cho, Junha Shin, Sohyun Hwang, Chanyoung Kim, Hongsuk Shim, Hyojin Kim, Hanhae Kim, '''Insuk Lee''', WormNet v3: a network-assisted hypothesis-generating server for Caenorhabditis elegans, '''''Nucleic Acids Res'''''. 2014 May 9 [http://www.ncbi.nlm.nih.gov/pubmed/24813450 Pubmed]
*34. Junha Shin, Tak Lee, Hanhae Kim and '''Insuk Lee''', Complementarity between distance- and probability-based methods of gene neighbourhood identification for pathway reconstruction. '''''Mol. BioSyst.''''', 10 (1), 24 - 29., (2014) [http://www.ncbi.nlm.nih.gov/pubmed/24194096 Pubmed]
*33. Hanhae Kim, Junha Shin, Eiru Kim, Hyojin Kim, Sohyun Hwang, Jung Eun Shim, '''Insuk Lee''', YeastNet v3: a public database of data-specific and integrated functional gene networks for Saccharomyces cerevisiae. '''''Nucleic Acids Research''''' 42 (D1): D731-D736., (2014) [http://www.ncbi.nlm.nih.gov/pubmed/24165882 Pubmed]

==2013==
*32. Eiru Kim, Hanhae Kim and '''Insuk Lee''', JiffyNet: a web-based instant protein network modeler for newly sequenced species. '''''Nucleic Acids Research''''' 41 (W1): W192-W197., (2013) [http://www.ncbi.nlm.nih.gov/pubmed/23685435 Pubmed][http://nar.oxfordjournals.org/content/early/2013/05/17/nar.gkt419.full.pdf+html pdf]
*31. '''Insuk Lee''', Network approaches to the genetic dissection of phenotypes in animals and humans. '''''Animal Cells and Systems''''' Vol.17,No.2,75-79(2013)[http://www.tandfonline.com/doi/abs/10.1080/19768354.2013.789076 Link]

==2012==
*30. Peggy I Wang, Sohyun Hwang, Rodney P Kincaid, Christopher S Sullivan, '''Insuk Lee*''', and Edward M Marcotte*. RIDDLE: Reflective diffusion and local extension reveal functional associations for unannotated gene sets via proximity in a gene network. '''''Genome Biology''''' 13:R125 (2012)[http://www.ncbi.nlm.nih.gov/pubmed/23268829 pubmed]
*29. Lee Chae*, '''Insuk Lee*''', Junha Shin, and Seung Yon Rhee*. Towards understanding how molecular networks evolve in plant. '''''Current Opinion in Plant Biology''''' 15:177-184 (2012)[http://www.ncbi.nlm.nih.gov/pubmed/22280840 pubmed] [[media:CurrOpinPlantBiol 15-177.pdf|pdf]]
*28. Stephanie M. Quanbeck, Libuse Brachova, Alexis A. Campbell, Xin Guan, Ann Perera, Kun He, Seung Y. Rhee, Preeti Bais, Julie A. Dickerson, Philip Dixon, Gert Wohlgemuth, Oliver Fiehn, Lenore Barken, Iris Lange, B. Markus Lange, '''Insuk Lee''', Diego Cortes, Carolina Salazar, Joel Shuman, Vladimir Shulaev, David V. Huhman, Lloyd W. Sumner, Mary R. Roth, Ruth Welti, Hilal Ilarslan, Eve S. Wurtele, and Basil J. Nikolau. Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of “unknown function”. '''''Frontiers in Plant Science''''' 3:1-12 (2012) [http://www.ncbi.nlm.nih.gov/pubmed/22645570/ pubmed][[media:Fpls-03-00015.pdf|pdf]]

==2011==
*27. '''Insuk Lee*''', Young-Su Seo, Dusica Coltrane, Sohyun Hwang, Taeyun Oh, Edward M. Marcotte*, and Pamela C. Ronald*. Genetic dissection of the biotic stress response using a genome-scale gene network for rice. '''''PNAS''''' 108(45):18548-53 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/22042862 pubmed] [[media:PNAS-2011-Lee-18548-53.pdf|pdf]]

*26. Sohyun Hwang, Seung Y. Rhee*, Edward M. Marcotte*, and '''Insuk Lee*'''. Systematic prediction of candidate gene function associated to phenotype traits using the probabilistic functional gene network of Arabidopsis thaliana. '''''Nature Protocols''''' 6:1429-1442 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21886106 pubmed][[media:2011.08.25.online.nprot.2011.372.pdf|pdf]]

*25. '''Insuk Lee''', Probabilistic functional gene societies. '''''Progress in Biophysics and Molecular Biology''''' 106:435-442 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21281658 pubmed] [[media:Publications_023_n.pdf|pdf]]

*24. '''Insuk Lee*''', U. Martin Blom, Peggy I. Wang, Jung Eun Shim, and Edward M. Marcotte*. Prioritizing candidate disease genes by network-based boosting of genome-wide association data. '''''Genome Research''''' 21:1109-1121 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21536720 pubmed] [[media:Publications_025_n.pdf|pdf]]

*23. Young-Su Seo, Mawsheng Chern, Laura E. Bartley, Muho Han, Ki-Hong Jung, '''Insuk Lee''', Harkamal Walia, Todd Richter, Xia Xu, Peijian Cao, Wei Bai, Rajeshwari Ramanan, Fawn Amonpant, Loganathan Arul, Patrick E. Canlas, Randy Ruan, Chang-Jin Park, Xuewel Chen, Sohyun Hwang, Jong-Seong Jeon, and Pamela C. Ronald. Towards establishment of a rice stress response interactome. '''''PLoS Genetics''''' 7(4):e1002020 (2011) [http://www.ncbi.nlm.nih.gov/pubmed/21533176 pubmed] [[media:Publications_024.pdf|pdf]]

==2010==
*22. Ni Huang, '''Insuk Lee''', Edward M.Marcotte, Matthew E.Hurles, Characterising and predicting haploinsufficiency in the human genome, '''''PLoS Genet.''''' 6(10):e1001154(2010) [http://www.ncbi.nlm.nih.gov/pubmed/20976243 pubmed] [[media:Publications_022.pdf|pdf]]

*21. Eiru Kim, Jaeyoon Shin and '''Insuk Lee''', Assessment of effectiveness of the network-guided genetic screen, '''''Mol Biosyst.''''' 6:1803-1806(2010) [http://www.ncbi.nlm.nih.gov/pubmed/20697632 pubmed] [[media:Publications_021.pdf|pdf]]

*20. '''Insuk Lee*''', Ben Lehner, Tanya Vavouri, Junha Shin, Andrew G. Fraser, and Edward M. Marcotte, Predicting genetic modifier loci using functional gene networks, '''''Genome Research''''', 20:1143-1153(2010) . co-corresponding author [http://www.ncbi.nlm.nih.gov/pubmed/20538624 pubmed] [[media:Publications_020.pdf|pdf]]

*19. '''Insuk Lee*''', Bindu Ambaru, Pranjali Thakkar, Edward M Marcotte*, Seung Y Rhee*, Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana, '''''Nature Biotechnology''''', 28:149-156 (2010). ''co-corresponding author'' [http://www.ncbi.nlm.nih.gov/pubmed/20118918 pubmed] [[media:Publications_019.pdf|pdf]]
==2009==
*18. '''Insuk Lee''' and Edward Marcotte. Effects of functional bias on supervised learning of a gene network model. '''In Methods in Molecular Biology''' Vol. 541, Computational Systems Biology (ed. R. Ireton, K. Montgomery, J. McDermott, R. Samudrala, R. Bumgarner). Totowa, THE HUMANA. p463-475 (2009) [http://www.ncbi.nlm.nih.gov/pubmed/19381535 pubmed] [[media:Publications_018.pdf|pdf]]

*17. Zhihua Li, '''Insuk Lee''', Emily Moradi, Nai-Jung Hung, Arlen W. Johnson, Edward M. Marcotte, Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics, '''''PLoS Biology''''', 7(10):e1000213 (2009) [http://www.ncbi.nlm.nih.gov/pubmed/19806183 pubmed] [[media:Publications_017.pdf|pdf]]

*16. Ryan S. Gray, Philip B. Abitua, Bogdan J. Wlodarczyk, Heather L. Szabo-Rogers, Otis Blanchard, '''Insuk Lee''', Greg S. Weiss, Karen J. Liu, Edward M. Marcotte, John B. Wallingford, Richard H. Finnell. The planar cell polarity effector protein Fuz is essential for targeted membrane trafficking, ciliogenesis, and mouse embryonic development, '''''Nature Cell Biology''''' 11:1225-32 (2009) '''''*Cover story''''' [http://www.ncbi.nlm.nih.gov/pubmed/19767740 pubmed] [[media:Publications_016.pdf|pdf]]
==2008==
*15. Ben Lehner* and '''Insuk Lee*'''. Network-guided genetic screening: building, testing, and using gene networks to predict gene function. '''''Brief. Funct. Genomic'''''. 7:217-227 (2008). '''''co-corresponding author''''' [http://www.ncbi.nlm.nih.gov/pubmed/18445637 pubmed] [[media:Publications_015.pdf|pdf]]

*14. '''Insuk Lee''' and Edward Marcotte. Integrating Functional Genomics Data. '''In Methods in Molecular Biology''' Vol. 453, Bioinformatics Vol. II (ed. Jonathan Keith). Totowa, THE HUMANA. p267-278 (2008) [http://www.ncbi.nlm.nih.gov/pubmed/18712309 pubmed] [[media:Publications_014.pdf|pdf]]

*13. '''Insuk Lee''', Ben Lehner, Catriona Crombie, Wendy Wong, Andrew G. Fraser, Edward M. Marcotte. A single gene network accurately predicts phenotypic effects of gene perturbation in ''Caenorhabditis elegans''. '''''Nature Genetics''''' 40:181-188 (2008). '''''*Cover story''''' [http://www.ncbi.nlm.nih.gov/pubmed/18223650 pubmed] [[media:Publications_013.pdf|pdf]]<br />This paper was the subject of the following commentary (Natalie de Souza, Networking on organism. Nature Methods 5:217), and minireviews (Von Stetina S. E. and Mango S. E. Wormnet: a crystal ball for Caenorhabditis elegans. Genome Biology 9:226. Borgwardt K. Predicting phenotypic effects of gene perturbations in C. elegans using an integrated network model. BioEssays 30:707)

==Before 2007==
*12. '''Insuk Lee''', Rammohan Narayanaswamy, Edward Marcotte. Bioinformatic prediction of yeast gene function. '''In METHOD IN MICROBIOLOGY''' Vol. 36, Yeast Gene Analysis (ed. Ian Stansfield and Mike Stark), Elsevier. p597-628, (2007) [[media:Publications_012.pdf|pdf]]

*11. Kris McGary, '''Insuk Lee''', Edward M. Marcotte. Broad network-based predictability of S. cerevisiae gene loss-of-function phenotypes. '''''Genome Biology''''' 8:R258 (2007) [http://www.ncbi.nlm.nih.gov/pubmed/18053250 pubmed] [[media:Publications_011.pdf|pdf]]

*10. '''Insuk Lee''', Zhihua Li, and Edward M. Marcotte. An improved bias-reduced probabilistic functional gene network of baker’s yeast ''Saccharomyces cerevisiae''. '''''PLOS One''''' 2:e988 (2007) [http://www.ncbi.nlm.nih.gov/pubmed/17912365 pubmed] [[media:Publications_010.pdf|pdf]]

*9. Hart G. Traver, '''Insuk Lee''', Edward Marcotte. A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. '''''BMC Bioinformatic''''' 8:236 (2007) [http://www.ncbi.nlm.nih.gov/pubmed/17605818 pubmed] [[media:Publications_009.pdf|pdf]]

*8. Insuk Lee, Shailesh V. Date, Alex T. Adai, Edward Marcotte. A Probabilistic functional network of yeast genes. '''''Science''''' 306:1555-1558, (2004) [http://www.ncbi.nlm.nih.gov/pubmed/15567862 pubmed] [[media:Publications_008.pdf|pdf]]

*7. Bork, P., Jensen, L.J., Von Mering, C., Ramani, A.K., '''Lee I''', Marcotte, E.M. Protein interaction networks from yeast to human. '''''Curr. Opin. Struct. Biol.''''' 14:292-9, (2004) [http://www.ncbi.nlm.nih.gov/pubmed/15193308 pubmed] [[media:Publications_007.pdf|pdf]]

*6. '''Insuk Lee''' and Rasika Harshey. Patterns of Sequence conservation at termini of LTR retrotransposons and DNA transposons in the human genome: Lessons from phage Mu. '''''Nucleic Acids Res.''''' 31:4531-4540, (2003)

*5. '''Insuk Lee''' and Rasika Harshey. The conserved CA/TG motif at Mu termini: T specifies stable transpososome assembly. '''''J. Mol. Biol.''''' 330:261-275, (2003)

*4. '''Insuk Lee''' and Rasika Harshey. Importance of the conserved CA dinucleotide at Mu termini. '''''J. Mol. Biol.''''' 314:433-444, (2001)

*3. Xue, Y., Bai, X., '''Lee, I.''', Kallstrom, G., Ho, J., Brown, J., Stevens, A., and Johnson, A. W. Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p. '''''Mol. Cell. Biol.''''' 20:4006-4015, (2000)

*2. Liu, J., Gong, Y., Prakash, O., Wen, L., '''Lee, I'''., Huang J.,-K., and Krishnamoorthi, R. NMR studies of internal dynamics of serine proteinase protein inhibitors: Binding region mobilities of intact and reactive-site hydrolyzed CMTI-III of the squash family and comparison with those of counterparts of CMTI-V of the potato I family. '''''Protein Science''''' 7:132-141, (1998)

*1. Wen, L., '''Lee, I.''', Chen, G., Huang, J.,-K., Gong, Y., and Krishnamoorthi, R. Changing the inhibitory specificity and function of CMTI-V by site-directed mutagenesis. '''''Biochem. Biophys. Res. Commun.''''' 207:897-902, (1995)

Welcome to Network Biology Laboratory

2015-06-04T14:30:32Z

Kskim:

__NOTOC__

{|border = "0" valign="top"
|rowspan="2" style="padding-right:20px;"|
[[File :Groupphoto_20150601_5.jpeg|580px|center|middle|Main Photo]]

|colspan=2|
=== Research Keyword Cloud ===
<div>{{#widget:AddHtml|content=<img src="cloud.jpg" alt="Word Cloud from Abstraction below publications" title="Word Cloud of NBL Publications' Abstract" />}}</div>
|-
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=== Oral Presentation ===
<pre>
JE Shim | T Lee
HJ Han** | HS Shim
KS Kim | ER Kim
CY Kim | DS Bae | BH Kang
</pre>
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=== Visitors Trend ===
[http://www2.clustrmaps.com/user/563d3fa7 http://www2.clustrmaps.com/stats/maps-no_clusters/www.netbiolab.org-thumb.jpg]
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===Contact Informations===
<pre>
Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
Office: Engineering Research Park B118DA
+82-70-8625-5205
</pre>
|}

2015-06-04T08:50:50Z

Kskim: /* Group Photo */

__NOTOC__
=='''Group Photo'''==
{|border="0" width="500"
|
[[File:2014group3.JPG|thumb|2014]]
|align="center"|
[[File:2013단체1.jpg|thumb|2013]]
|align="center"|
[[File:People_Album_Spring2012_main.jpg|thumb|2012]]
|-
|align="center"|
[[File:People_Album_Spring2011_05.jpg|thumb|2011]]
|align="center" |
[[File:People_Album_Spring2010_01.jpg|thumb|2010]]
|}
----
*[[People:Album:2015 Group photo | 2016 Group photo]]
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*[[People:Album:2015 Teachers' day | 2015 Teacher's day]]
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*[[People:Album:2014 Summer MT | 2014 Summer MT]]
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*[[People:Album:2014 Group photo | 2014 Group photo]]
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*[[People:Album:2013 Summer MT | 2013 Summer MT]]
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*[[People:Album:2013 Group photo | 2013 Group photo]]
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*[[People:Album:Teachers' day 2013| 2013 May, Teachers' day]]
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*[[People:Album:ThanksGivingDay_2012| 2012 Nov, Thanksgiving Day]]
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*[[People:Album:MT_2012| 2012 June, Summer MT]]
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*[[People:Album:GroupPhoto_2012_Spring|2012 April, Group Photo]]
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*[[People:Album:Keystone_2012| 2012 February, Keystone]]
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*[[People:Album:MT_2011| 2011 August, Summer MT]]
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*[[People:Album:ISSCR_2011| 2011 June, ISSCR]]
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*[[People:Album:RECOMB_2011| 2011 March, RECOMB2011]]
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*[[People:Album:AYRCOB5th_2011| 2011 August, Ayrcob 5th]]
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*[[People:Album:Teachers_Day_2011| 2011 May, Teacher's day]]
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*[[People:Album:GroupPhoto_2011_Spring|2011 March, Group Photo]]
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*[[People:Album:APBC2011|2011 February, APBC (Incheon)]]
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*[[People:Album:ISMB2010|2010 June, ISMB(Boston)]]
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*[[People:Album:Sue2010|2010 June, Sue Rhee visit]]
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*[[People:Album:Cup_cake_2010| 2010 May, Cup Cake professor]]
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*[[People:Album:Edward_Marcotte_at_NBL|2010 May, Edward Marcotte and @NBL Reunion]]
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*[[People:Album:GroupPhoto_2010_Spring|2010 March, Group Photo]]
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*[[People:Album:KSBSB2009|2009 November, KSBSB (Pusan)]]
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*[[People:Album:ICSB2009|2009 August, ICSB (Stanford)]]
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*[[People:Album:winter_MT_2008|2008 December, Winter MT]]

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