Domain-based PPI network by Weighted Mutual Information (WMI)
We present a method for inferring accurate functional PPIs based on the similarity of domain compositions between proteins by weighted mutual information that assigned different weights to domains based on their genome-wide frequencies. Catapult is a computer algorithm for associating new genes with traits, phenotypes, and diseases. Catapult leverages hundreds of thousands of known individual gene-phenotype associations from humans, mice, yeast, Arabidopsis, and C. elegans, and interprets them with the aid of a genome-scale functional network of human genes (HumanNet) in a graph-based formalism in order to rank new candidate genes
Citation: Jung Eun Shim and Insuk Lee, Weighted mutual information analysis sub-stantially improves domain-based functional network models (Under review)
