Difference between revisions of "Domain2Pathway by Pathway Specificity (PS)"

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*[http://www.netbiolab.org/wiki/images/0/09/WMI_program.zip Source codes for PS calculation]
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*[http://www.netbiolab.org/wiki/images/0/09/WMI_program.zip Source codes and datafile for PS calculation]
*[http://www.netbiolab.org/wiki/images/1/1e/SC_WMI_12K.txt Example datafile]
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Revision as of 16:16, 22 September 2017

Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. Nevertheless, some domains may exist in specific pathways. We therefore developed a network-based scoring scheme to quantify specificity of domain-pathway associations, and then used it to classify 'pathway-specific domains (PSDs)' and 'non-specific domains (NSDs)'.



Citation : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Network-based identification of pathway-specific protein domains and their implications for human diseases (under review)

Contact Information : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)

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