Difference between revisions of "Domain2Pathway by Pathway Specificity (PS)"

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Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways.
 
Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways.
 
Nevertheless, some domains may exist in specific pathways.
 
Nevertheless, some domains may exist in specific pathways.
We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations''', and then used it to classify ''''pathway-specific domains (PSDs)'''' and ''''non-specific domains (NSDs)''''.
+
We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations (PS)''', and then used it to classify ''''Pathway-Specific Domains (PSDs)'''' and ''''Non-Specific Domains (NSDs)''''.
  
  

Revision as of 16:27, 22 September 2017

Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. Nevertheless, some domains may exist in specific pathways. We therefore developed a network-based scoring scheme to quantify specificity of domain-pathway associations (PS), and then used it to classify 'Pathway-Specific Domains (PSDs)' and 'Non-Specific Domains (NSDs)'.



Citation : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Network-based identification of pathway-specific protein domains and their implications for human diseases (under review)

Contact Information : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)

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