Difference between revisions of "Research"

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(Research Philosophy)
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==Research Philosophy==
 
==Research Philosophy==
'''4P Research (Play, Ponder, Pride, Provide)'''
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'''4P Research (Play, Ponder, Pride, Provide)'''  
 
*'''Play''': Your lab is your playground.
 
*'''Play''': Your lab is your playground.
 
*'''Ponder''': Think harder for less labor.
 
*'''Ponder''': Think harder for less labor.
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==Collaborators==
 
==Collaborators==
 +
'''Human/Animal Systems Biology'''
 
*[http://www.marcottelab.org/index.php/Main_Page Edward Marcotte, University of Texas at Austin, USA]
 
*[http://www.marcottelab.org/index.php/Main_Page Edward Marcotte, University of Texas at Austin, USA]
 
*[http://www.fraserlab.org/ Andrew Fraser, University of Toronto, Canada]
 
*[http://www.fraserlab.org/ Andrew Fraser, University of Toronto, Canada]
 
*[http://www.crg.es/ben_lehner Ben Lehner, Systems Biology Unit, EMBL-CRG, Spain]
 
*[http://www.crg.es/ben_lehner Ben Lehner, Systems Biology Unit, EMBL-CRG, Spain]
 +
*[http://www.sanger.ac.uk/research/faculty/mhurles/ Matthew Hurles, Sanger Institute, UK]
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*[http://www.chamc.co.kr/professor/drleedr/ Dongryul Lee, Cha Medical School, Korea]
 +
*[http://web.yonsei.ac.kr/labsi/ Sangjun Ha, Yonsei University, Korea]
 +
 +
'''Crop/Plant Systems Biology'''
 
*[http://dpb.carnegiescience.edu/labs/rhee-lab Sue Rhee, Carnegie Institution of Science, USA]
 
*[http://dpb.carnegiescience.edu/labs/rhee-lab Sue Rhee, Carnegie Institution of Science, USA]
 
*[http://indica.ucdavis.edu/ Pamela Ronald, University of California at Davis, USA]
 
*[http://indica.ucdavis.edu/ Pamela Ronald, University of California at Davis, USA]
*[http://www.sanger.ac.uk/research/faculty/mhurles/ Matthew Hurles, Sanger Institute, UK]
 
 
*[http://www.biology.duke.edu/benfeylab/index.htm Philip Benfey, Duke University, USA]
 
*[http://www.biology.duke.edu/benfeylab/index.htm Philip Benfey, Duke University, USA]
*Sangsun Yoon, Yonsei Medical School, Korea
+
*[http://bti.cornell.edu/TomBrutnell.php#page=ResearchSummary, Cornell Universy, USA]  
*[http://www.chamc.co.kr/professor/drleedr/ Dongryul Lee, Cha Medical School, Korea]
+
 
 +
'''Microbial Systems Biology'''
 
*[http://www.bahnlab.com/ Yongsun Bahn, Yonsei University, Korea]
 
*[http://www.bahnlab.com/ Yongsun Bahn, Yonsei University, Korea]
*[http://web.yonsei.ac.kr/labsi/ Sangjun Ha, Yonsei University, Korea]
+
*Sangsun Yoon, Yonsei Medical School, Korea
 +
*[http://web.biosci.utexas.edu/whiteley_lab/pages/home.html Marvin Whiteley, University of Texas at Austin, USA]

Revision as of 10:43, 13 February 2012

Contents

Research Summary

The ultimate goal of biological research is to manipulate traits that are important for medicine, agriculture, and bio-industry. This challenging task first requires good understanding of association between genotype and phenotype. Because of high complexity of genotype as well as phenotype, complexity of the genotype-phenotype association could be even untouchable by combinatorial explosion of the number of possible associations. Therefore, modern genetics needs to be more systematic and predictive. Recently we proposed network-guided approach for genetics of complex traits. First, we construct probabilistic functional gene networks for cells or organisms by benchmarking and integrating heterogeneous multi-omics data that are in general publicly available. Then, using guilt-by-association, and other algorithms of network propagation of known biological information, we predict gene functions, phenotypic effect of loss-of-function, and epistatic interaction. The information can contribute to reconstruction of map between genotype and phenotype. The network-guided genetics method has been effectively applied for various organisms; from simple microbe yeast, to multicellular animal C. elegans, to the reference plant Arabidopsis, to the reference crop rice, and to the human.

Research Philosophy

4P Research (Play, Ponder, Pride, Provide)

  • Play: Your lab is your playground.
  • Ponder: Think harder for less labor.
  • Pride: Be proud of your research.
  • Provide: Provide your discovery for the people, for they provide their money for your research.

The more learn, the less know.

Research Highlight

Collaborators

Human/Animal Systems Biology

Crop/Plant Systems Biology

Microbial Systems Biology

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