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| − | ==Research Summary==
| + | [[File:research_vision_20230823.png|center|1200px]] |
| − | The ultimate goal of biological research is to manipulate traits that are important for medicine, agriculture, and bio-industry. This challenging task first requires good understanding of association between genotype and phenotype. Because of high complexity of genotype as well as phenotype, complexity of the genotype-phenotype association could be even untouchable by combinatorial explosion of the number of possible associations. Therefore, modern genetics needs to be more systematic and predictive. Recently we proposed network-guided approach for genetics of complex traits. First, we construct probabilistic functional gene networks for cells or organisms by benchmarking and integrating heterogeneous multi-omics data that are in general publicly available. Then, using guilt-by-association, and other algorithms of network propagation of known biological information, we predict gene functions, phenotypic effect of loss-of-function, and epistatic interaction. The information can contribute to reconstruction of map between genotype and phenotype. The network-guided genetics method has been effectively applied for various organisms; from simple microbe yeast, to multicellular animal C. elegans, to the reference plant Arabidopsis, to the reference crop rice, and to the human.
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| − | ==Collaborators==
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| − | *[http://www.marcottelab.org/index.php/Main_Page Edward Marcotte, University of Texas at Austin, USA]
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| − | *Andrew Fraser, University of Toronto, Canada
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| − | *Ben Lehner, Systems Biology Unit, EMBL-CRG, Spain
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| − | *Sue Rhee, Carnegie Institution of Science, USA
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| − | *Pamela Ronald, University of California at Davis, USA
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| − | *Matthew Hurles, Sanger Institute, UK
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| − | *Philip Benfey, Duke University, USA
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| − | *Sangsun Yoon, Yonsei Medical School, Korea
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| − | *Dongryul Lee, Cha Medical School, Korea
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| − | *Yongsun Bahn, Yonsei University, Korea
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| − | *Sangjun Ha, Yonsei University, Korea
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| − | ==Functional Networks==
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| − | *[[file:Tools_FunctionalNetLogo.jpg|150px|link=http://www.functionalnet.org]]
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| − | **[[file:Tools_AraNetLogo.jpg|150px|link=http://www.functionalnet.org/aranet]]
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| − | **[[file:Tools_WormNetLogo.jpg|150px|link=http://www.functionalnet.org/wormnet]]
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