Domain2Pathway by Pathway Specificity (PS)
Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. Nevertheless, some domains may exist in specific pathways. We therefore developed a network-based scoring scheme to quantify specificity of domain-pathway associations (PS), and then used it to classify 'Pathway-Specific Domains (PSDs)' and 'Non-Specific Domains (NSDs)'.
Citation : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Pathway-specific protein domains are predictive for human diseases. PLoS Comput Biol 15(5):e1007052
Contact Information : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)