View source for Domain2Pathway by Pathway Specificity (PS)

Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways.
Nevertheless, some domains may exist in specific pathways.
We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations''', and then used it to classify ''''pathway-specific domains (PSDs)'''' and ''''non-specific domains (NSDs)''''.


*[http://www.netbiolab.org/wiki/images/0/09/WMI_program.zip Source codes and datafile for PS calculation]


'''''Citation''''' : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Network-based identification of pathway-specific protein domains and their implications for human diseases (under review)

'''''Contact Information''''' : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)