View source for Domain2Pathway by Pathway Specificity (PS)

Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways.
Nevertheless, some domains may exist in specific pathways.
We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations (PS)''', and then used it to classify ''''Pathway-Specific Domains (PSDs)'''' and ''''Non-Specific Domains (NSDs)''''.


*[https://netbiolab.org/wiki/images/6/68/Ps.zip Source codes and data files for PS calculation]


'''''Citation''''' : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Pathway-specific protein domains are predictive for human diseases. PLoS Comput Biol 15(5):e1007052

'''''Contact Information''''' : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)