Difference between revisions of "Domain2Pathway by Pathway Specificity (PS)"
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Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. | Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. | ||
Nevertheless, some domains may exist in specific pathways. | Nevertheless, some domains may exist in specific pathways. | ||
| − | We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations''', and then used it to classify '''' | + | We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations (PS)''', and then used it to classify ''''Pathway-Specific Domains (PSDs)'''' and ''''Non-Specific Domains (NSDs)''''. |
| − | *[ | + | *[https://netbiolab.org/wiki/images/6/68/Ps.zip Source codes and data files for PS calculation] |
| − | + | ||
| − | '''''Citation''''' : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, | + | '''''Citation''''' : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Pathway-specific protein domains are predictive for human diseases. PLoS Comput Biol 15(5):e1007052 |
'''''Contact Information''''' : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr) | '''''Contact Information''''' : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr) | ||
Latest revision as of 19:33, 10 May 2019
Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. Nevertheless, some domains may exist in specific pathways. We therefore developed a network-based scoring scheme to quantify specificity of domain-pathway associations (PS), and then used it to classify 'Pathway-Specific Domains (PSDs)' and 'Non-Specific Domains (NSDs)'.
Citation : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Pathway-specific protein domains are predictive for human diseases. PLoS Comput Biol 15(5):e1007052
Contact Information : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)
