Difference between revisions of "Domain2Pathway by Pathway Specificity (PS)"
From Bioinformatics Lab
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Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. | Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. | ||
Nevertheless, some domains may exist in specific pathways. | Nevertheless, some domains may exist in specific pathways. | ||
| − | We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations''', and then used it to classify '''' | + | We therefore developed a network-based scoring scheme to quantify '''specificity of domain-pathway associations (PS)''', and then used it to classify ''''Pathway-Specific Domains (PSDs)'''' and ''''Non-Specific Domains (NSDs)''''. |
Revision as of 16:27, 22 September 2017
Protein domains are basic functional units of proteins, yet domain-based pathway annotations for proteins are still challenging tasks because many domains are pervasive among diverse pathways. Nevertheless, some domains may exist in specific pathways. We therefore developed a network-based scoring scheme to quantify specificity of domain-pathway associations (PS), and then used it to classify 'Pathway-Specific Domains (PSDs)' and 'Non-Specific Domains (NSDs)'.
Citation : Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee and Insuk Lee, Network-based identification of pathway-specific protein domains and their implications for human diseases (under review)
Contact Information : Insuk Lee (insuklee[at]yonsei[dot]ac[dot]kr)
